The 49ers attempted a seven-lateral desperation play in the final seconds and reached Rams territory before Jake Brendel’s toss to Brandon Aiyuk bounded out of bounds to end one of the 49ers’ most frustrating losses in years. It was also their first regular-season defeat at SoFi Stadium in five years.

The Los Angeles Rams came into Week 3 as sizable underdogs against the San Francisco 49ers, especially being the home team. After their 41-10 loss to the Arizona Cardinals, few people were picking the Rams to take down the defending NFC champions.

The Los Angeles Rams avoided a dreaded 0-3 start on Sunday by beating the San Francisco 49ers in dramatic fashion. They came back from a 10-point fourth-quarter deficit, stealing a win from the defending NFC champions to secure their first win of the season – a much-needed win,