Administration of Substances to Laboratory Animals: Routes …
WEBAdministration of substances directly into the mouth, admixed in diet or other foodstuffs, or by orogastric or nasogastric gavage is common in laboratory animal medicine and research. Per rectum administration of substances by enema or suppository is less common in animals than in humans.
WEBFeb 28, 2022 · This document is designed to provide information about the volume or amount of a substance to be given to laboratory animals depending on route of administration. All procedures must be approved by the Institutional Animal Care and Use Committee (IACUC).
WEBlist the maximum intramuscular dose of 0.05 ml/kg/site for rodents, rabbits and small nonhuman primates. Diehl and Hull list the dose volume per site without factoring in the animal body weight.
Common Technical Procedures – Animal Care & Use
WEBMar 9, 2021 · Rabbit Oral Gavage 1 – A 6-8 French feeding tube as appropriate for the size of the rabbit will be selected. 2 – The tube will be measured for proper length from the tip of the nose to the last rib and marked accordingly.
Administration of Substances to Laboratory Animals: Equipment ...
WEBSome of these devices include a head gate that secures around the rabbit's neck. Special care must be taken when using a head gate to ensure that the animal can breathe freely. Rabbits may panic and injure their spine or limbs in these restraint devices, and acclimation to the equipment is advised. Figure 7.
WEBAdult rabbit: 0.2 ml per animal . 3. Intradermal i. Maximum dose for all species is 0.05-0.1 ml/site. 4. Retro-orbital i. Maximum values: adult mice 0.15ml; neonatal mice 0.01 ml 5. Rectal i. Maximum value: mouse <0.5 ml 6. Intraosseous i. Maximum value: mouse 0.20 ml, rat and guinea pig 0.5 ml, rabbit 1-5 ml 7. Footpad Injections i.
Guidelines on Administration of Substances to Laboratory Animals
WEBSep 8, 2021 · Gavage: Administration of substances via a tube that is passed through the nose or mouth into the esophagus or stomach. Rectal: Administration of substances into the rectum.
WEBOct 12, 2016 · Clean gavage needles or feeding tubes should be used for each oral dosing group. Needles must not be recapped prior to placing in sharps containers. Substances to be injected must be sterile or filtered and must not cause long lasting irritation at the site of injection unless approved by the ACUC.
A technique for intragastric gavage of radiolabeled liquid ... - Nature
WEBThe author describes a method of intragastric gavage in rabbits using a pediatric feeding tube. Researchers used this technique to administer radiolabeled cholesterol in a pilot study of...
Van Dyk, A., Rickers, M. 2010. A technique for single-person oral ...
WEBThe physiologic and anatomic structure of rabbits can cause high mortality rates in rabbit oral gavage. Rabbits are capable of a wide variety of jaw movement due to 3 jaw-closing muscle groups (masseter, temporalis, pterygoid).
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